2-FLUORO-6-METHOXYPHENYLBORONIC ACID
(2-Fluoro-6-methoxyphenyl)boronic acid
CAS: 78495-63-3
Molecular Formula: C7H8BFO3
2-FLUORO-6-METHOXYPHENYLBORONIC ACID - Names and Identifiers
| Name | (2-Fluoro-6-methoxyphenyl)boronic acid |
| Synonyms | 2-Fluoro-6-methoxyph 2-Borono-3-fluoroanisole 3-Fluoroanisole-2-boronic acid 2-Fluoro-6-Methoxyphenylboroni 2-Fluoro-6-methoxyphenylboronic acid 2-FLUORO-6-METHOXYPHENYLBORONIC ACID 2-FLUORO-6-METHOXYLPHENYLBORONIC ACID 2-Fluoro-6-methoxybenzeneboronic acid (2-Fluoro-6-methoxyphenyl)boronic acid (2-FLUORO-6-METHOXYBENZENE)BORONIC ACID |
| CAS | 78495-63-3 |
| InChI | InChI=1/C7H8BFO3/c1-12-6-4-2-3-5(9)7(6)8(10)11/h2-4,10-11H,1H3 |
| InChIKey | XOVMDVZAWWQSDC-UHFFFAOYSA-N |
2-FLUORO-6-METHOXYPHENYLBORONIC ACID - Physico-chemical Properties
| Molecular Formula | C7H8BFO3 |
| Molar Mass | 169.95 |
| Density | 1.26±0.1 g/cm3(Predicted) |
| Melting Point | 120-125 °C (lit.) |
| Boling Point | 303.1±52.0 °C(Predicted) |
| Flash Point | 137.1°C |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.00042mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 8.35±0.58(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.503 |
| MDL | MFCD02179483 |
2-FLUORO-6-METHOXYPHENYLBORONIC ACID - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
2-FLUORO-6-METHOXYPHENYLBORONIC ACID - Reference Information
| introduction | 2-fluoro -6-methoxyphenylboronic acid is an aryl boronic acid. aryl boronic acid can be widely used as a safe and environmentally friendly new arylation reagent in the scientific research and production of various fine chemicals containing aromatic structures such as medicine, pesticides, advanced materials, etc. The reaction of arylboronic acid and halides plays an important role in the synthesis of drugs today. This kind of reaction was first proposed by the Japanese scientist Suzuki team and won the Nobel Prize in Chemistry in 2010. |
| use | 2-fluoro-6-methoxyphenylboronic acid can be used to prepare Kras mutant inhibitors with the following structure. In view of Kras mutation, the research progress has been slow for many years. Because there is no suitable drug action site on Kras, the affinity between Kras and GTP after mutation is very strong, and the concentration of GTP in cells is high, resulting in no small molecule can combine competitively with GTP. |
Last Update：2024-04-09 20:52:54
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